In Dragon Age 2, if you click on a companion they have one-liners they will say, that usually reflect either where they are, or something to do with where you are in questlines.
If you have someone besides Hawke selected and click on Hawke, s/he even has some reactive comments.
I had Isabela selected and tried to click on a locked chest. I clicked on Hawke instead. She said 'I'm sorry. Was I in your way?"